BDBM50038002 Benzamidine (Protonated)::CHEMBL20936::CHEMBL537204::benzamidine

SMILES c1ccc(cc1)C(=N)N

InChI Key InChIKey=PXXJHWLDUBFPOL-UHFFFAOYSA-N

Data  29 KI  2 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50038002   

TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKd:  4.55E+5nMAssay Description:Binding affinity to thrombin (unknown origin) by displacement titration based isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetKallikrein-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataIC50: 5.01E+5nMAssay Description:Inhibition of human recombinant 6His-Q-FLAG-tagged KLK5 expressed in baculovirus infected Sf9 insect cells using rhodamine-labelled tripeptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKd:  1.82E+4nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAnionic trypsin(Bovine)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKd:  1.48E+7nMAssay Description:log Kd (Binding affinity against specified protein) value of the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Daiichi Asubio Medical Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of f11aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKd:  3.55E+5nMAssay Description:Binding affinity to thrombin (unknown origin) by direct isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  31nMAssay Description:In vitro binding affinity by measuring the inhibition of bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  31nMAssay Description:Inhibitory Activity against bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Protherics Molecular Design

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  200nMAssay Description:Inhibitory concentration against human Coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  300nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  300nMAssay Description:Inhibitory Activity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Protherics Molecular Design

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  410nMAssay Description:Binding affinity was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.24E+3nMAssay Description:Binding affinity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.24E+3nMAssay Description:Binding affinity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAcrosin(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  4.00E+3nMAssay Description:Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetIonotropic glutamate receptor subunit Delta2(African clawed frog)
State University of New York

Curated by PDSP Ki Database
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.84E+4nMAssay Description:Binding affinity against bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.84E+4nMAssay Description:Binding affinity against bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory concentration against bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.20E+4nMAssay Description:Competitive inhibition of bovine beta trypsin using Bz-Arg-NH-Np as substrate at pH 7 at 30 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.50E+4nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibitory activity against bovine trypsin expressed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  2.20E+5nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.50E+5nMpH: 7.5Assay Description:Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  2.58E+5nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Institut FüR Biochemie

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  9.10E+5nMAssay Description:Inhibitory activity against human tissue-type plasminogen activator expressed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Institut FüR Biochemie

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  8.90E+5nMAssay Description:Inhibitory activity against bovine thrombin expressed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Institut FüR Biochemie

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Bovine)
Institut FüR Biochemie

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibitory activity against bovine coagulation factor X expressed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.98E+5nMAssay Description:Competitive inhibition of esterase activity of human plasmin assessed as assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  4.00E+5nMAssay Description:Inhibition of matriptase-SP1 (615 to 855) (unknown origin) expressed in Escherichia coli BL21(DE3) using Boc-Gln-Ala-Arg-7-amido-4-methyl coumarin hy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  5.00E+5nMAssay Description:Competitive inhibition of esterase activity of human plasmin assessed as assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  3.16E+5nMAssay Description:Competitive inhibition of esterase activity of human plasmin assessed as assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPlasminogen(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKi:  2.51E+6nMAssay Description:Competitive inhibition of esterase activity of human plasmin assessed as assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed