BDBM50036629 Avanafil::CHEBI:66876::Stendra::TA-1790

SMILES COc1ccc(cc1Cl)CNc2c(cnc(n2)N3CCC[C@H]3CO)C(=O)NCc4ncccn4

InChI Key InChIKey=WEAJZXNPAWBCOA-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50036629   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Dog)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50036629(CHEBI:66876 | Avanafil | Stendra | TA-1790)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50036629(CHEBI:66876 | Avanafil | Stendra | TA-1790)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50036629(CHEBI:66876 | Avanafil | Stendra | TA-1790)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50036629(CHEBI:66876 | Avanafil | Stendra | TA-1790)
Affinity DataKi:  5nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)