BDBM50034501 (S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid::(S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic acid::CHEMBL30285

SMILES N[C@H](C(O)=O)c1cc(=O)[nH]o1

InChI Key InChIKey=IRJCBFDCFXCWGO-UHFFFAOYSA-N

Data  7 KI  21 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50034501   

TargetMetabotropic glutamate receptor 1(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  6.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1c in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  1.10E+5nMAssay Description:Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR3 in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  1.00E+6nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR6 in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  5.90E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR4a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  6.00E+3nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Mouse)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50: >1.00E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  3.50E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR2 in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  8.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5b in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  6.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  4.40E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1b in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi:  1.74E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK3a expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi:  2.43E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK1(Q)1b expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi:  3.23E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK2(VCR)a expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed