BDBM50033741 (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl acetate::1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl acetate::Acetic acid (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-4-methyl-pent-3-enyl ester::Acetic acid 1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-4-methyl-pent-3-enyl ester::CHEMBL403516::acetylshikonin

SMILES [#6]\[#6](-[#6])=[#6]\[#6]=[#6](-[#8]-[#6](-[#6])=O)-c1cc(-[#8])c2c(-[#8])ccc(-[#8])c2c1-[#8]

InChI Key InChIKey=LRLDMDMGLLXGLN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50033741   

TargetDNA topoisomerase 1(Human)
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibitory activity against DNA topoisomerase-1 obtained from Hela cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 2(Human)
National Research Laboratory of Lipid Metabolism and Atherosclerosis

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human ACAT2 expressed in Hi5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
National Research Laboratory of Lipid Metabolism and Atherosclerosis

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of human ACAT1 expressed in Hi5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Brevig Mission/1/1918 ...)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 4.14E+4nMAssay Description:Inhibition of recombinant influenza A virus H1N1 A/Bervig_Mission/1/18 sialidase activity using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Chinese Academy of Science

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 3.73E+4nMAssay Description:Tested for 50% inhibition against TelomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of His tagged SARS-CoV-2 PLpro using Z-RLRGG-AMC as substrate assessed as substrate cleavage preincubated for 60 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 350nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed