BDBM50033376 CHEMBL3357634

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C(\F)=C\CN(C)C

InChI Key InChIKey=MJLGATKKRYTQPD-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50033376   

TargetRAC-beta serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type AKT2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 75nMAssay Description:Inhibition of wild type HER2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 23nMAssay Description:Inhibition of wild type HER4 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of wild type PDGFRalpha (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of wild type PDGFRbeta (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type JAK2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type SYK (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type ALK (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type AKT1 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type c-Met (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 6.81E+3nMAssay Description:Inhibition of wild type FLT3 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of wild type ABL (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of wild type SRC (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed