BDBM50028893 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide::CHEMBL517::DISOPYRAMIDE::alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide::gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide

SMILES CC(C)N(CC[C@](c1ccccc1)(c2ccccn2)C(=O)N)C(C)C

InChI Key InChIKey=UVTNFZQICZKOEM-UHFFFAOYSA-N

Data  2 KI  16 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50028893   

TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 8.17E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.04E+6nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 2(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human OCT2 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMultidrug and toxin extrusion protein 2(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MATE2-K expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human MATE1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 2(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataKi:  3.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50028893(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)
Affinity DataKi:  6.20E+4nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed