BDBM50026752 1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester::1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester(Meperidine)::4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium::CHEMBL607::Demerol::MEPERIDINE::MEPERIDINE HYDROCHLORIDE::Mepergan::Pethidine::ethyl 1-methyl-4-phenylpiperidine-4-carboxylate

SMILES CCOC(=O)C1(CCN(C)CC1)c1ccccc1

InChI Key InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N

Data  10 KI  12 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50026752   

TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 315nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataEC50:  700nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 500nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 7.59E+4nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 324nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 2.37E+3nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataEC50:  9.40E+3nMAssay Description:Activity at human cloned mu opioid receptor assessed as reversal of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  412nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter (SERT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  413nMAssay Description:Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  413nMAssay Description:Inhibition of [3H]paroxetine binding to rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  451nMAssay Description:Binding affinity against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  920nMAssay Description:Binding affinity at mu-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  920nMAssay Description:Inhibition of [3H]DAMGO binding to mu-opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  1.78E+4nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  1.78E+4nMAssay Description:Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi:  1.78E+4nMAssay Description:Displacement of [3H]WIN-35428 from dopamine transporter (DAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed