BDBM50024294 SP-600125

SMILES Oc1c2cccc3N=Nc(c23)c2ccccc12

InChI Key InChIKey=KRIUNPBAQZGFQA-UHFFFAOYSA-N

Data  4 IC50  38 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 50024294   

TargetSerine/threonine-protein kinase 16(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  510nMAssay Description:Average Binding Constant for STK16; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Mouse)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  220nMAssay Description:Average Binding Constant for STK3_m; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  3.70E+3nMAssay Description:Average Binding Constant for CSNK1G1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  1.00E+3nMAssay Description:Average Binding Constant for MKNK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  1.80E+3nMAssay Description:Average Binding Constant for MARK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  84nMAssay Description:Average Binding Constant for JNK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  35nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  300nMAssay Description:Average Binding Constant for CLK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  4.10E+3nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 16(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  180nMAssay Description:Average Binding Constant for PCTK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.30E+3nMAssay Description:Average Binding Constant for SLK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  98nMAssay Description:Average Binding Constant for TTK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  38nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  480nMAssay Description:Average Binding Constant for TNIK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  460nMAssay Description:Average Binding Constant for PIM2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.40E+3nMAssay Description:Average Binding Constant for p38-gamma; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  1.70E+3nMAssay Description:Average Binding Constant for RPS6KA5 (Kin.Dom 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-fused full length human TTK compound pre-incubated for 15 mins prior ATP addition by MBP-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin) by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin) by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetDeath-associated protein kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  610nMAssay Description:Average Binding Constant for DAPK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  22nMAssay Description:Average Binding Constant for JNK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.20E+3nMAssay Description:Average Binding Constant for RPS6KA2 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  5.30E+3nMAssay Description:Average Binding Constant for Aurora3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  480nMAssay Description:Average Binding Constant for PHkg2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  100nMAssay Description:Average Binding Constant for JNK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1G(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  4.20E+3nMAssay Description:Average Binding Constant for CAMK1G; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  4.00E+3nMAssay Description:Average Binding Constant for EPHA3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 38-like(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.30E+3nMAssay Description:Average Binding Constant for STK38L; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  1.40E+3nMAssay Description:Average Binding Constant for CAMK1D; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  980nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK3(Mouse)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  680nMAssay Description:Average Binding Constant for ULK3 m; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  7.50E+3nMAssay Description:Average Binding Constant for CAMKK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.10E+3nMAssay Description:Average Binding Constant for STK17A; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  25nMAssay Description:Average Binding Constant for BIKE; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  770nMAssay Description:Average Binding Constant for STK18; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  260nMAssay Description:Average Binding Constant for CLK4; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  2.20E+3nMAssay Description:Average Binding Constant for STK4; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  3.20E+3nMAssay Description:Average Binding Constant for CDK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  3.10E+3nMAssay Description:Average Binding Constant for CSNK1E; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDeath-associated protein kinase 3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  410nMAssay Description:Average Binding Constant for DAPK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed