BDBM50019056 (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid::([Met]-enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid([Met]-enkephalin::2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-1-oxo-3-phenyl-propylamino]-4-methylsulfanyl-butyric acid::2-[1-[1-amino-2-(4-hydroxyphenyl)-(1S)-ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-4-methylsulfanyl-(2S)-butanoic acid::2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid::CHEMBL13786::H-Tyr-Gly-Gly-Phe-Met-OH::Met5-Enkephalin::[Met5]-enkephalin::met-enkephalin

SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=YFGBQHOOROIVKG-UHFFFAOYSA-N

Data  20 KI  10 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50019056   

LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 18nMAssay Description:Compound was tested for its ability to displace [3H]naloxone from Opioid receptors in absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for its binding affinity against enkephalin delta receptor using [3H]DPDPE as ligand in rat cerebrum in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for its binding affinity against enkephalin mu receptor using [3H]PL-017 as ligand in rat cerebrum in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  620nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 200nMAssay Description:Inhibitory potency against Opioid receptor mu 1 in longitudinal muscle preparation of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 13nMAssay Description:Inhibitory potency against delta Opioid receptor delta 1 in longitudinal muscle preparation of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human cloned delta opioid receptor assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 240nMAssay Description:Compound was tested for its ability to displace [3H]naloxone from Opioid receptors in presence of NaCl (100 mM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 90nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 13nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its binding affinity against enkephalin kappa receptor using [3H]U-69593 as ligand in guinea pig cerebrum in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50: 6.40nMAssay Description:Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by biolum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  309nMAssay Description:Agonist activity at mu opioid receptor in rat brain membranes assessed as stimulation of [35S]GTPgammaS binding after 60 mins in presence of GDPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataEC50:  304nMAssay Description:Agonist activity at mu opioid receptor in rat brain membranes assessed as stimulation of [35S]GTPgammaS binding after 60 mins in presence of GDPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  0.650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.28nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-Diprenorphine from human MOR receptor expressed in CHO-K1 cells assessed as inhibition constant measured for 1 hr by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  6.90nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  7.30nMAssay Description:Inhibition of [3H]DTLET binding torat brain membrane Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid libraryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  28nMAssay Description:Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOprd1b protein(Zebrafish)
Instituto De Qu£Mica Avanzada De Catalu£A (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]DPN from zebrafish delta 1b opioid receptor expressed in HEK293 cell membranes after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetNociceptin receptor(Guinea pig)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  277nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Zebrafish)
Instituto De Qu£Mica Avanzada De Catalu£A (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  684nMAssay Description:Displacement of [3H]DPN from zebrafish mu opioid receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
Mcgill University

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2013
Entry Details
PubMed
TargetNociceptin receptor(Mouse)
Mcgill University

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2013
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  4.47E+3nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Pennsylvania

Curated by PDSP Ki Database
LigandPNGBDBM50019056(2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from human cloned kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed