BDBM50018822 CHEMBL3286812

SMILES CNC(=O)c1ccc(F)cc1[C@@H](C)Oc1nc(cnc1N)-c1cccnc1OC

InChI Key InChIKey=AMLQLZSHSQNJKQ-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50018822   

TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataIC50: 312nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  0.850nMAssay Description:Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  8.20nMAssay Description:Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  8.20nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed