BDBM50017721 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::CHEMBL516::CYPROHEPTADINE

SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12

InChI Key InChIKey=AYFAGRAOJPSHSH-UHFFFAOYSA-N

Data  72 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 79 hits for monomerid = 50017721   

LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant Set7/9 (unknown origin) expressed in Escherichia coli BL21 (DE3) using biotinylated histone H3-derived peptide/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SET7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant SET7/9 (unknown origin) using biotinylated histone H3-derived peptide/SAM as substrate after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKd:  5.40E+3nMAssay Description:Dissociation constant against histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against LTD4-induced contraction of guinea pig ileum at 10 uM concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataIC50: 140nMAssay Description:Binding affinity at dopamine D2 receptor by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
UniversitÉ

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity at 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-5HT from human 5-HT2B receptor expressed in CHO-K1 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  1.54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat cerebral cortex 5-HT2A receptor after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  2.23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  2.88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]- QNB binding at the muscarinic-cholinergic binding site of rat brain S1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor of rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  11nMAssay Description:Binding affinity to 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  11.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Mouse)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  22.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  28nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  33.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  34.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  47.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  50nMAssay Description:Binding affinity towards 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  50nMAssay Description:Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  77.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 79 total ) | Next | Last >>