BDBM50017691 CHEMBL126075::dilazep

SMILES COc1cc(cc(c1OC)OC)C(=O)OCCCN2CCCN(CC2)CCCOC(=O)c3cc(c(c(c3)OC)OC)OC

InChI Key InChIKey=QVZCXCJXTMIDME-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50017691   

TargetEquilibrative nucleoside transporter 1(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50017691(CHEMBL126075 | dilazep)
Affinity DataIC50: 18nMAssay Description:Inhibition of human ENT1 expressed in porcine PK15NTD cells by cell-based [3H]5-uridine uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEquilibrative nucleoside transporter 2(Rat)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50017691(CHEMBL126075 | dilazep)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of rat ENT2 expressed in rat H9c2 cells by cell-based 3H[5-]uridine uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50017691(CHEMBL126075 | dilazep)
Affinity DataIC50: 600nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 5(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017691(CHEMBL126075 | dilazep)
Affinity DataIC50: 5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 4(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017691(CHEMBL126075 | dilazep)
Affinity DataIC50: 2.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed