BDBM50015266 CHEMBL3263053

SMILES CN(C)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(ccc23)-c2cn[nH]c2)cn1

InChI Key InChIKey=NCXHAHGMYXETMO-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50015266   

TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50015266(CHEMBL3263053)
Affinity DataIC50: 173nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as decrease in phosphorylation of PLC-gamma1 by immunodetection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50015266(CHEMBL3263053)
Affinity DataIC50: 25nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as reduction in PLC-gamma phosphorylation after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50015266(CHEMBL3263053)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full-length ITK (unknown origin) using biotin-EQEDEPEGIYGVLF-NH2 as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50015266(CHEMBL3263053)
Affinity DataKi:  0.100nMAssay Description:Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50015266(CHEMBL3263053)
Affinity DataKi:  15nMAssay Description:Inhibition of human His-tagged full length AURKA using kemptide peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed