BDBM50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine)::CHEMBL94739::Femoxetine

SMILES COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1

InChI Key InChIKey=OJSFTALXCYKKFQ-UHFFFAOYSA-N

Data  27 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50014247   

TargetSodium-dependent serotonin transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  9.08nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  9.10nMAssay Description:Tested in vitro for dopamine(DA) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  92nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  120nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  121nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  184nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  407nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  590nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.04E+3nMAssay Description:Tested in vitro for dopamine(DA) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetBeta-arrestin-2(Bovine)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.91E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.97E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  2.05E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  2.29E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  3.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
Target5-hydroxytryptamine 1D receptor(Bovine)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  3.72E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  4.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  9.33E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed