BDBM50014089 CHEMBL1236726

SMILES CN(C)CCCN(C)[C@H]1CCN(C1)C(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccccc1

InChI Key InChIKey=LWWQYOWAPGRPRH-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50014089   

TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014089(CHEMBL1236726)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of p53 protein binding to MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014089(CHEMBL1236726)
Affinity DataKi:  109nMAssay Description:Displacement of fluorescent P4 peptide from recombinant human MDM2 (18 to 125) expressed in Escherichia coli BL21(DE3) RIL expression system after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014089(CHEMBL1236726)
Affinity DataKi:  109nMAssay Description:Binding affinity to human MDM2 assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014089(CHEMBL1236726)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity to human MDM4 assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed