BDBM50012780 (3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl-methanone::CHEMBL8846::Prifelone

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(=O)c1cccs1

InChI Key InChIKey=WAAVMZLJRXYRMA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50012780   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780(Prifelone | CHEMBL8846 | (3,5-Di-tert-butyl-4-hydr...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human neutrophil 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50012780(Prifelone | CHEMBL8846 | (3,5-Di-tert-butyl-4-hydr...)
Affinity DataIC50: 500nMAssay Description:Inhibitory concentration against prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780(Prifelone | CHEMBL8846 | (3,5-Di-tert-butyl-4-hydr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration against arachidonate 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50012780(Prifelone | CHEMBL8846 | (3,5-Di-tert-butyl-4-hydr...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human platelet Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed