BDBM50009860 2-(6-Methoxy-naphthalen-2-yl)-propionic acid::2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen)::2-(6-methoxy-2-naphthyl)propanoic acid::2-(6-methoxynaphthalen-2-yl)propanoic acid::CHEMBL154::Naproxen::Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid

SMILES C[C@@H](c1ccc2cc(ccc2c1)OC)C(=O)O

InChI Key InChIKey=CMWTZPSULFXXJA-UHFFFAOYSA-N

Data  5 KI  10 IC50

PDB links: 11 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50009860   

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 350nMAssay Description:Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Rat)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 2.43E+4nMAssay Description:Compound was tested in vitro for inhibition of human umbilical cord endothelial cells(ECV-304 cell line) Prostaglandin G/H synthase 2 at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataKi:  9.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-methoxynaphthalen-2-yl)propanoic acid | Napro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)