BDBM50008029 (4-Methoxy-phenyl)-[2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone::(s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone::CHEMBL13178::PRAVADOLINE

SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12

InChI Key InChIKey=MEUQWHZOUDZXHH-UHFFFAOYSA-N

Data  3 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50008029   

TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.16E+3nMAssay Description:Concentration of compound required to inhibit 50% of [3H]WIN-55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.16E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]WIN-55212-2 binding in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetCannabinoid receptor 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 453nMAssay Description:Agonist activity at CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin-H2 D-isomerase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.50E+3nMAssay Description:Compound was tested for inhibitory activity against prostaglandin synthetase in mouse brain microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProstaglandin-H2 D-isomerase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.50E+3nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.16E+3nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.16E+3nMAssay Description:Displacement of 0.5 nM [3H](R)-(+)-WIN-55212-2 from Cannabinoid receptor of rat cerebellar membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProstaglandin-H2 D-isomerase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]-CP55940 from rat CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataKi:  4.57E+8nMAssay Description:Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]WIN-55212-2 in rat forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50008029((s-cis) -(4-Methoxy-phenyl)-[2-methyl-1-(2-morphol...)
Affinity DataKi:  3.98E+5nMAssay Description:Binding affinity at cannabinoid receptor 1 using rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed