BDBM50007692 8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL1204189::CHEMBL35057::TIOSPERONE

SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2ccccc12

InChI Key InChIKey=ZFZPJDFBJFHYIV-UHFFFAOYSA-N

Data  19 KI  13 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50007692   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 47nMAssay Description:Binding affinity against Alpha-1 adrenergic receptor of rat cerebral cortex with [3H]WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against glutamate receptor was measured using radioligand [3H]-kainic acid binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2 receptor in rat cerebral cortex tissue using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue with [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity against Dopamine receptor D2 receptor of rat corpus striatal tissue with [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 8nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 18nMAssay Description:Compound was measured for affinity at 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 22nMAssay Description:Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor measured using radioligand ([3H]spiperone) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 13nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKd:  0.963nMAssay Description:Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 47nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKd:  0.334nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against alpha-2 adrenergic receptor was measured using radioligand ([3H]clonidine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataIC50: 2nMAssay Description:Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  0.640nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  9.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  9.77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(4) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  13.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Washington

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  950nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  1.29E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50007692(TIOSPERONE | CHEMBL35057 | CHEMBL1204189 | 8-[4-(4...)
Affinity DataKi:  3.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed