BDBM50005075 (2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-tetrahydro-quinoline-2-carboxylic acid::5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-tetrahydro-quinoline-2-carboxylic acid::CHEMBL287327

SMILES c1ccc(cc1)NC(=O)N[C@H]2C[C@@H](Nc3c2c(cc(c3)Cl)Cl)C(=O)O

InChI Key InChIKey=UCKHICKHGAOGAP-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50005075   

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005075(CHEMBL287327 | (2R,4S)-5,7-Dichloro-4-(3-phenyl-ur...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of [3H]- glycine binding to N-methyl-D-aspartate glutamate receptor from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005075(CHEMBL287327 | (2R,4S)-5,7-Dichloro-4-(3-phenyl-ur...)
Affinity DataIC50: 4nMAssay Description:Inhibition of the binding of [3H]L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005075(CHEMBL287327 | (2R,4S)-5,7-Dichloro-4-(3-phenyl-ur...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of binding of [3H]glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005075(CHEMBL287327 | (2R,4S)-5,7-Dichloro-4-(3-phenyl-ur...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of [3H]glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)