BDBM50001266 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid anion::5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid(DCKA)::5,7-Dichloro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid::5,7-dichlorokynurenic acid::CHEMBL50267

SMILES c1c(cc(c2c1nc(cc2O)C(=O)O)Cl)Cl

InChI Key InChIKey=BGKFPRIGXAVYNX-UHFFFAOYSA-N

Data  4 KI  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50001266   

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataIC50: 860nMAssay Description:Ability to displace strychnine-insensitive [3H]glycine binding to rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataEC50:  330nMAssay Description:Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstarted by the ability to inhibit the binding of the channel-blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataIC50: 90nMAssay Description:Inhibition of specific binding of [3H]glycine to NMDA receptors, in rat cortical membranes at 32 uM conc.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataIC50: 140nMAssay Description:Ability of compound to compete with [3H]glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataKi:  40nMAssay Description:Tested for the ability to displace [3H]glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]glycine from glycine site on the NMDA receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataKi:  40nMAssay Description:Ability to displace strychnine-insensitive [3H]glycine binding to rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001266(CHEMBL50267 | 5,7-dichlorokynurenic acid | 5,7-Dic...)
Affinity DataKi:  90nMAssay Description:Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]Gly as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)