BDBM468882 US10807959, Example B15

SMILES COc1cc(cc(c1)OC)CNC(=O)c2ccc(c(c2)CNC3=NCCN3)F

InChI Key InChIKey=VDAMWMOTTUWVPR-UHFFFAOYSA-N

Data  1 KI  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 468882   

TargetWD repeat-containing protein 5(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM468882(US10807959, Example B15)
Affinity DataKd:  1.30nMAssay Description:Inhibition of human WDR5 WIN site expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM468882(US10807959, Example B15)
Affinity DataKi:  1.33nMAssay Description:FPA Assay protocol adopted from Karatas et al. (J. Med. Chem. 2010, 5179.; J. Amer. Chem. Soc. 2013, 669.): WDR5 (Δ23, residues 24-334), is expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)