BDBM4567 4-anilinoquinazoline deriv. 2::BMC163482 Compound 1::CHEMBL285063::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide::US9422297, PD168393

SMILES C=CC(=O)Nc1ccc2c(c1)c(ncn2)Nc3cccc(c3)Br

InChI Key InChIKey=HTUBKQUPEREOGA-UHFFFAOYSA-N

Data  40 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 4567   

TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.69nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BmxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 expressed in mouse BAF3 cells assessed as cytotoxicityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Blk expressed in mouse BAF3 cells assessed as cytotoxicityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 303nMAssay Description:Inhibition of Bmx expressed in mouse BAF3 cells assessed as cytotoxicityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 324nMAssay Description:Inhibition of wild type Bmx expressed in mouse BAF3 cells assessed as cytotoxicityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR-TK in human A431 cell lysate assessed as reduction in EGF stimulated kinase activity after 60 mins using biotinylated peptide subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase STK11(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Lkb1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 152nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of c-src in by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Fyn(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of Fyn expressed in Escherichia coli C43 by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Irreversible inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 18nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 114nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.81E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 130nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 521nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of ERBB2 receptor kinase in MDA-MB-453 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 24nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 12nMAssay Description:Inhibition of HER4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 5.47E+3nMAssay Description:Inhibition of BlkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed