BDBM438155 US10618897, Example 23

SMILES c1cc2c(c(c1)Br)C3(CCN(CC3)C(=O)c4ccc5c(n4)cn[nH]5)C(=O)N2CC(=O)NCC(F)(F)F

InChI Key InChIKey=UXEXYURPAPXPSR-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 438155   

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM438155(US10618897, Example 23)
Affinity DataIC50: 25.6nMAssay Description:An in vitro binding competition assay was performed to evaluate the effect of the compounds of present invention on DDR1 protein.Binding Competition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM438155(US10618897, Example 23)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant GST-tagged human DDR1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDiscoidin domain-containing receptor 2(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM438155(US10618897, Example 23)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant GST-tagged human DDR2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM438155(US10618897, Example 23)
Affinity DataIC50: 29nMAssay Description:Inhibition of DDR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed