BDBM435794 US10577373, Compound I-954

SMILES CNc1cc(nc2n1ncc2C(=O)N[C@@H]3C[C@@H]3F)NC4=CC=CN(C4=O)c5c(cccn5)F

InChI Key InChIKey=FFJRAFFUQOURPS-UHFFFAOYSA-N

Data  11 IC50  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 435794   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JAK in human PBMC cells assessed as IL-12-induced phosphorylation of STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JAK in human PBMC cells assessed as GM-CSF-induced phosphorylation of STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataIC50: 22nMAssay Description:Inhibition of TYK2 in human PBMC cells assessed as IL-12 induced phosphorylation of STAT4 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd:  0.0680nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed