BDBM433323 US10561657, Ruxolitinib::US10617692, Ruxolitinib::US11414413, Example Ruxolitinib::US20240140952, Compound (rac)-Ruxolitinib

SMILES N#CCC(C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=HFNKQEVNSGCOJV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 433323   

TargetTyrosine-protein kinase JAK2(Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 20nMAssay Description:A testing platform for kinase activity of JAK2 (wild type and V617F mutant type) was established based on Homogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 20nMAssay Description:A testing platform for kinase activity of JAK2 (wild type and V617F mutant type) was established based on Homogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 10nMAssay Description:A testing platform for kinase activity of JAK2 was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 3.30nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 2.80nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 390nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Centaurus Biophrama

US Patent
LigandPNGBDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 0.920nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent