BDBM431871 1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azabicyclo[3.1.0]hexan-4-yl)ethynyl)phenyl)-1H- pyrazolo[3,4-b]pyridine-3-carboxamide::US10550117, Compound 1

SMILES CN1[C@@H]2C[C@@H]2[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O

InChI Key InChIKey=GMAWUPHGBKLOEK-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 431871   

LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 53nMAssay Description:Inhibition of NIK in HEK-293 cells assessed as inhibition of NIK-dependent NF-kappaB response element expression by firefly luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 55nMAssay Description:Inhibition of NIK in HUVEC cells assessed as inhibition of anti-LTf3R-stimulated p52 nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 2nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 330nMAssay Description:Inhibition of NIK in human primary B cell assessed as inhibition of CD40L-stimulated nuclear translocation of p52 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 210nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  0.880nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  64nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed