BDBM412666 (S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-isopropyl-6-((trans-4-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide::US10399976, Compound 2::US10807980, Compound 2::US11535614, Compound 2
SMILES CCS(=O)(=O)c1ccc(nc1)CNC(=O)c2cc3c(nc2)[C@@H](N(C3)CC4CCC(CC4)C(F)(F)F)C(C)C
InChI Key InChIKey=XUYMIRYNRKXKOR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 412666
Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were tested for ROR gamma inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human RORgamma by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of RORgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of RORgammat (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to ROR gamma in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair
Affinity DataKi: <100nMAssay Description:Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...More data for this Ligand-Target Pair