BDBM390179 US9951086, Example 68

SMILES CCOc1cc2c(cc1NC(=O)c3cccc(n3)C(F)(F)F)cn(n2)CC(=O)N4CCN(CC4)C

InChI Key InChIKey=AIMNCVIDWQOVPW-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390179   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM390179(US9951086, Example 68)
Affinity DataIC50: 5nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM390179(US9951086, Example 68)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human IRAK4 expressed in baculovirus infected Hi-5 cells using biotinylated-Ahx-KKARFSRFAGSSPSQASFAEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)