BDBM387845 US10294227, Code 402

SMILES CN(C)C1CCN(CCn2nc(-c3cnc4[nH]ccc4c3)c3c(N)ncnc23)CC1

InChI Key InChIKey=MJQGHLODJHABRA-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 387845   

TargetTyrosine-protein kinase ABL1(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
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TargetTyrosine-protein kinase Blk(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
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TargetTyrosine-protein kinase Fgr(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase FRK(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fyn(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
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TargetTyrosine-protein kinase HCK(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Yes(Human)
University Court of The University of Edinburgh

US Patent
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent