BDBM383210 US10278929, Compound 1::US11337935, Compound 1

SMILES OC(=O)c1ccc(cc1)-c1c(F)cccc1F

InChI Key InChIKey=CWWIIKLXUPZDOG-UHFFFAOYSA-N

Data  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 383210   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM383210(US10278929, Compound 1 | US11337935, Compound 1)
Affinity DataKd:  72.5nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 383210   

CellTransthyretin(Human)
Leland Stanford Junior University

US Patent
SyringePNGBDBM383210(US10278929, Compound 1 | US11337935, Compound 1)
ITC DataΔG°: -9.74kcal/mole −TΔS°: 21.7kcal/mole ΔH°: -31.5kcal/mole logk: 1.41E+7
pH: 7.5 T: 25.00°C 
In DepthDetails
Go to US Patent