BDBM380028 4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]phenyl}-1,2- dihydrophthalazin-1- one::US9926282, Example 23

SMILES c1ccc2c(c1)CCN2C(=O)Cc3ccc(cc3)C4=NNC(=O)c5c4cccc5

InChI Key InChIKey=COYVFENBIAJDFY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380028   

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50: 550nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50: 100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50: 340nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)