BDBM377919 2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide::US10266526, Compound 50

SMILES c1cc2c(cc1C(=O)NC3CCNCC3)CC(=O)N2

InChI Key InChIKey=SWMKOYKJOHHEQD-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 377919   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.22E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)