BDBM375544 4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile::US9908886, Example 96

SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1

InChI Key InChIKey=FWRFPHJSGLYXTD-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 375544   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 86nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 646nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 321nMAssay Description:Inhibition of eIF4E phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 86nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 64nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of N-terminal GST-fused human full length recombinant MNK2 (1 to 465 residues) expressed in baculovirus-infected Sf21 cells using TATKSGST...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-fused human full length recombinant MNK1 (1 to 424 residues) expressed in baculovirus-infected Sf21 cells using TATKSGST...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 64nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 321nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 86nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 64nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent