BDBM373711 US10246444, Example 40

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)CC1CCSS1

InChI Key InChIKey=QCVAULIYZATFDX-UHFFFAOYSA-N

Data  13 IC50  21 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 373711   

TargetCytochrome P450 2C9(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  14nMAssay Description:Binding affinity to human partial length EGFR G719S mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  1.00E+4nMAssay Description:Inhibition of human partial length EGFR L858R/T790M mutant (R669 to V1011 residues) expressed in mammalian expression system by competition binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to human partial length EGFR L747-E749del/A750P mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length EGFR S752-I759 deletion mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  48nMAssay Description:Binding affinity to human partial length EGFR E746-A750 deletion mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 120nMAssay Description:Inhibition of probe binding to wild type EGFR (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to human partial length EGFR G719C mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to human partial length EGFR L861Q mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  12nMAssay Description:Binding affinity to human partial length EGFR L747-S752del/P753S mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under full equilibrating...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-751,753-758,760-1210](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [G719C](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [G719S](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L861Q](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-746,748-750,752-1210](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd: >1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 11nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  120nMAssay Description:Binding affinity to human partial length wild type EGFR (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataIC50: 160nMAssay Description:Inhibition of probe binding to HER2 (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373711(US10246444, Example 40)
Affinity DataKd:  13nMAssay Description:Binding affinity to human partial length EGFR L747-T751del/Sins mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed