BDBM371932 3-[(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 33::US10435407, Example 33

SMILES c1ccc(cc1)N2CN(C(=O)C23CCN(CC3)C(=O)c4ccc5c(c4)cn[nH]5)Cc6nc(no6)C7CC7

InChI Key InChIKey=SCNJPRUXBGWNTB-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371932   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM371932(3-[(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(...)
Affinity DataIC50: 13.8nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM371932(3-[(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(...)
Affinity DataIC50: 13.8nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)