BDBM35905 Tolfenamic acid::cid_610479::flufenamic acid analogue, 32

SMILES Cc1c(cccc1Cl)Nc2ccccc2C(=O)O

InChI Key InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N

Data  2 KI  8 IC50  1 Kd  1 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 35905   

TargetAndrogen receptor(Human)
St. Jude Research Hospital

LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 5.79E+4nMpH: 7.2 T: 2°CAssay Description:A radiolabeled ligand competition scintillation proximity assay (SPA) for the androgen receptor (AR) using Ni-coated 384-well FlashPlates. It measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
TargetCysteine protease ATG4B(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 8.17E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetPhospholipase A2(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 7.74E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2012
Entry Details
PCBioAssay
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 4.00E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataKd:  150nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
St. Jude Research Hospital

LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 4.70E+4nMAssay Description:Activity at androgen receptor ligand binding domain assessed as inhibition of SRC2-3 interaction after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 880nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated 10 mins followed by substrate addition and measured after 2 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome c oxidase subunit 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataKi:  8nMAssay Description:Inhibition of human AKR1C3 using S-(+)-1,2,3,4-tetrahydro-1-naphthol as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataKi:  6.10E+3nM ΔG°:  -13.5kcal/moleT: 2°CAssay Description:Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450550 nm following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed