BDBM35283 CHEMBL551991::cyanoguanidine, 3

SMILES Cc1cc2cc(ccc2o1)N=C(NC#N)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O

InChI Key InChIKey=BQUXAJWDRCSKFN-UHFFFAOYSA-N

Data  6 KI  15 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 35283   

TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C19 in human TC5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C9 in human TC5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2D6 in human TC5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 using BZR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human TC5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  6.5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of t-PAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >7.80E+3nMAssay Description:Inhibition of u-PAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.60E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.80E+4nMAssay Description:Inhibition of activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed