BDBM35012 benzothienopyrimidinone deriv., 12b

SMILES CN(C)CC1=Nc2c3cc(ccc3sc2C(=O)N1)/C=C/C4CC4

InChI Key InChIKey=CPHAAKSWOQSYIW-UHFFFAOYSA-N

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35012   

TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

LigandPNGBDBM35012(benzothienopyrimidinone deriv., 12b)
Affinity DataKi:  1nM ΔG°:  -12.2kcal/molepH: 7.5 T: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-2(Human)
Abbott Laboratories

LigandPNGBDBM35012(benzothienopyrimidinone deriv., 12b)
Affinity DataKi:  2nM ΔG°:  -11.9kcal/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2009
Entry Details Article
PubMed