BDBM350100 5-(3,4-dichlorobenzyl)-1- (S,S,-dioxo- tetrahydrothiophen-3-yl)- 1H-pyrazol[3,4- d]pyrimidin-4(5H)-one::US10208043, # 1::US10941146, # 1

SMILES Clc1ccc(Cn2cnc3n(ncc3c2=O)C2CCS(=O)(=O)C2)cc1Cl

InChI Key InChIKey=PPZWUQVIYVDZNY-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 350100   

TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350100(US10208043, # 1 | 5-(3,4-dichlorobenzyl)-1- (S,S,-...)
Affinity DataIC50: 734nMAssay Description:About 150,000 compounds were screened. These chemical compounds were from the LOPAC 1280 collection, the Prestwick chemical library, the Pharmakon co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350100(US10208043, # 1 | 5-(3,4-dichlorobenzyl)-1- (S,S,-...)
Affinity DataIC50: 6.76E+4nMAssay Description:Inhibition of human (His8)2-tagged fascin (1 to 493 residues) expressed in Escherichia coli BL21(DE3) pLysS assessed as reduction in F-actin bundling...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350100(US10208043, # 1 | 5-(3,4-dichlorobenzyl)-1- (S,S,-...)
Affinity DataKd:  2.93E+4nMAssay Description:Binding affinity to human fascin (1 to 493 residues) expressed in Escherichia coli BL21(DE3) pLysS by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350100(US10208043, # 1 | 5-(3,4-dichlorobenzyl)-1- (S,S,-...)
Affinity DataIC50: 734nMAssay Description:A high throughput assay was developed to screen for fascin specific inhibitors. Purified polymerized F-actin with or without fascin were mixed and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
Go to US Patent