BDBM33411 β-Thujaplicinol::hydroxytropolone, 3

SMILES CC(C)C1=CC=C(C(=O)C(=C1)O)O

InChI Key InChIKey=HVGNSPLLPQWYGC-UHFFFAOYSA-N

Data  10 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 33411   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 660nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein(HIV-1)
Mcgill University

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 3.80E+3nMpH: 7.8 T: 2°CAssay Description:To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Food and Drug Administration

Curated by ChEMBL
LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 260nMAssay Description:Inhibition of human immunodeficiency virus-1 reverse transcriptase associated RNase H activity using using 18-nucleotide 3,-fluorescein-labeled RNA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus 2)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 250nMAssay Description:Inhibition of RNase H activity of HIV-2 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HIV-1 BH10 reverse transcriptase RNase H activity expressed in Escherichia coli using [32P]-labeled template primer 31Trna/21P as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Food and Drug Administration

Curated by ChEMBL
LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 210nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H activity expressed in Escherichia coli using 32P-labeled template 31Trna RNA and DNA oligonucleotide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of wild-type recombinant HIV-1 group M subtype B BH10 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant His-tagged wild-type HIV-1 group M subtype B BH10 reverse transcriptase-associated RNase H activity harboring p66/p51 hetro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 210nMAssay Description:Inhibition of HIV-1 RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)