BDBM33397 2,4-diaminofuro[2,3-d]pyrimidine, 3::E/Z ratio=3:1

SMILES CC(C)/C(=C/c1coc2c1c(nc(n2)N)N)/c3ccccc3OC

InChI Key InChIKey=ZBHMLBFDTQKTKI-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 33397   

TargetEpidermal growth factor receptor(Human)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 1.11E+5nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 2.00E+5nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 5.00E+5nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 7.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 6.35E+3nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 1.19E+4nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Mouse)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 4.14E+3nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM33397(E/Z ratio=3:1 | 2,4-diaminofuro[2,3-d]pyrimidine, ...)
Affinity DataIC50: 3.40E+4nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2009
Entry Details Article
PubMed