BDBM332659 US10196374, Example 1
SMILES CC(C)[C@@H]([C@@H](c1ccccc1)Oc2ccc3c(c2)cnn3C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F
InChI Key InChIKey=ZQFNDBISEYQVRR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 332659
Affinity DataEC50: 10nMAssay Description:A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 158nMAssay Description:A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...More data for this Ligand-Target Pair
Affinity DataIC50: 631nMAssay Description:TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Modulation of glucocorticoid receptor in rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to human ERbeta expressed in Sf9 cells by fluoligand binding-based fluorescence polarization methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to human ERalpha expressed in Sf9 cells by fluoligand binding-based fluorescence polarization methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Modulation of glucocorticoid receptor in rat whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Transrepression of GR in human whole blood assessed as inhibition of LPS-induced TNF-alpha release preincubated for 45 mins followed by LPS addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in human T47D cells after 1200 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]methyltrienolone from androgen receptor in human LNCaP cells after 1440 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Displacement of [3H]-aldosterone from human mineralocorticoid receptor LBD (729 to 984 residues) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Transactivation activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells incubated for 24 hrs by beta-galactosidase repo...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of dexamethasone induced tran...More data for this Ligand-Target Pair