BDBM328996 1137477-07-6::US11787792, Compound Y-081::US9663503, Compound Y-081

SMILES COC(=O)c1cnc(Nc2cnc(cn2)C#N)cc1NCC1CNCCO1

InChI Key InChIKey=PHPWNBVMNTWSJB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 328996   

TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CHK2 (unknown origin) using Biotin-KKKVSRSGLYRSPSMPENLNRPR peptide as substrate incubated for 30 mins in presence of ATP by dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 310nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328996(US9663503, Compound Y-081 | 1137477-07-6 | US11787...)
Affinity DataIC50: 2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent