BDBM323415 3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol::US10188615, Example 4::US10639286, Example 4

SMILES NCCC(O)c1cccc(OCC2CCCCC2)c1

InChI Key InChIKey=WJIGGYYSZBWCGC-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 323415   

TargetRetinoid isomerohydrolase(Human)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 1.00E+3nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetRetinaldehyde-binding protein 1(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J Biol. Chem. 274:8577-85 (1999).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetRetinaldehyde-binding protein 1(Human)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J Biol. Chem. 274:8577-85 (1999).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataEC50:  172nMAssay Description:Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production using all-trans-retinol as substrate pre-incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 190nMAssay Description:Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 172nMAssay Description:Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323415(3-Amino-1-(3-(cyclohexylmethoxy)Phenyl)Propan-1-Ol...)
Affinity DataIC50: 200nMAssay Description:Inhibition of RPE65 in bovine microsomes assessed as reduction on 11-cis-retinol production incubated for 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed