BDBM320910 (R)- or (S)-1-{1-[4- (Difluoromethoxy)phenyl]ethyl}- 6-hydroxy-3- (trifluoromethyl)-1,5- dihydro-4H- pyrazolo[3,4- d]pyrimidin-4-one::US10174037, Example 315::US10174037, Example 316

SMILES CC(c1ccc(OC(F)F)cc1)n1nc(c2c1nc(O)[nH]c2=O)C(F)(F)F

InChI Key InChIKey=QCAKIXIPIFTYBD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320910   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 320910BDBM320910(US10174037, Example 316 | (R)- or (S)-1-{1-[4- (Di...)
Affinity DataKi:  6.10nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 320910BDBM320910(US10174037, Example 316 | (R)- or (S)-1-{1-[4- (Di...)
Affinity DataKi:  629nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent