BDBM31756 6,7-dimethyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid::MLS-0007635.0001::cid_646406

SMILES Cc1ccc2C3C=CCC3C(Nc2c1C)C(O)=O

InChI Key InChIKey=UORZCPZFZNBVDZ-UHFFFAOYSA-N

Data  31 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 31756   

TargetDual specificity protein phosphatase 6(Rat)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 4.25E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetNuclear receptor subfamily 4 group A member 1(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.89E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.59E+4nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 4.81E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetHeat shock cognate 71 kDa protein(Human)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 2.19E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 8.68E+3nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetZinc finger protein mex-5(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataEC50:  2.17E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2011
Entry Details
PCBioAssay
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 2.12E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 3.17E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetPOsterior Segregation(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataEC50:  3.74E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2011
Entry Details
PCBioAssay
TargetLarge T antigen(SV40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 9.14E+4nMAssay Description:A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag Southern Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3G(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 858nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3G(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 3.03E+4nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3A(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.70E+3nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 6His-tagged recombinant MKP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using OMFP as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein phosphatase 6(Rat)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 6.00E+3nMpH: 7.0 T: 2°CAssay Description:Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, La Jolla, CA) Network: NIH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2009
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 4.73E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 4.20E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 2.05E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 7.12E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 3.02E+4nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 5.43E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.77E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetGlyceraldehyde-3-phosphate dehydrogenase(Human)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 8.08E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay
TargetHeat shock 70 kDa protein 1A(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 7.18E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 6.20E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Columbia University Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 940nMAssay Description:LYP, a lymphocyte specific protein tyrosine phosphatase that plays a critical regulatory role in T cell receptor signaling, is encoded by the PTPN22 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 Phosphatase Secondary Selectivity Assay has been developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) part ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.06E+4nMAssay Description:The Cdc25B Phosphatase Secondary Selectivity Assay has been developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) part...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 4.04E+4nMAssay Description:The MKP-1 Phosphatase Dose Response Confirmation and Secondary Selectivity/Specificity Assay has been Developed and Run at the University of Pittsbur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2011
Entry Details
PCBioAssay
TargetGag-Pol polyprotein(HIV-1)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 1.03E+3nMpH: 8.0 T: 2°CAssay Description:A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2009
Entry Details
PCBioAssay