BDBM31148 3-hydroxyquinolin-2(1H)-one, 2::US9701638, 1

SMILES c1ccc2c(c1)C=C(C(=O)N2)O

InChI Key InChIKey=BERPCVULMUPOER-UHFFFAOYSA-N

Data  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 31148   

TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-aspartate oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 855nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  13nMAssay Description:Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Rat)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 215nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Rat)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 94nMAssay Description:Inhibition of rat spinal DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Pig)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 100nMAssay Description:Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 42nMAssay Description:Inhibition of DAAO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHemagglutinin(Influenza A virus (strain swl A/California/04/2009...)
Rutgers, The State University of New Jersey

US Patent
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 2.40E+4nMpH: 7.5Assay Description:The PAN domain has been shown to cleave ssRNA as well as ssDNA. To demonstrate the inhibition of endonuclease cleavage by PAN, a high throughput assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Pig)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  150nMAssay Description:Binding affinity to pig kidney DAAO by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Lille

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed