BDBM31023 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole::CHEMBL2011570::CHEMBL27811::MLS000093715::SMR000029333::cid_2761023

SMILES C1CC(=CCN1)c1c[nH]c2ccccc12

InChI Key InChIKey=CIRSPTXGPFAXRE-UHFFFAOYSA-N

Data  8 KI  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 31023   

Target5-hydroxytryptamine receptor 1A(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataEC50:  5.00E+4nMpH: 7.4 T: 2°CAssay Description:A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1E(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataEC50:  15.7nMpH: 7.4 T: 2°CAssay Description:The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2009
Entry Details
PCBioAssay
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataIC50: 5.96E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataIC50: 2.53E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetSphingosine 1-phosphate receptor 3(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataEC50: >4.00E+4nMAssay Description:External Assay ID: S1P3_EC50_CS_5HT1e_Agonist Name: S1P3 Dose Response Assay Counterscreen for 5-Hydroxytryptamine(Serotonin) Receptor Subtype 1E ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataIC50: 3.70nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataEC50:  163nMAssay Description:Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]paroxetine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  189nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  190nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  191nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  200nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  204nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  296nMAssay Description:Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM31023(CHEMBL2011570 | SMR000029333 | MLS000093715 | cid_...)
Affinity DataKi:  632nMAssay Description:Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes using 11 concentration of ligand after 90 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed