BDBM309529 3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione::US10945994, Compound 1::US9603836, Compound 1::US9603836, Compound 1a::US9949951, 1a
SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
InChI Key InChIKey=MXKLDYKORJEOPR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 309529
Affinity DataIC50: 1.50E+3nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of IDO1 in irradiated human SKOV3 cells co-cultured with human PBMCs assessed as rescue of T-cell proliferation by [3H]-thymidine incorpor...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant IDO1 assessed as reduction in kynurenine production incubated fro 15 mins using L-Trp substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of IDO1 in mouse P815 Clone 12 cells assessed as reduction in kynurenine production incubated for 16 to 18 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant full-length human IDO1 by mass spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.78E+5nMAssay Description:Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.27E+5nMAssay Description:Inhibition of mouse IDO2 expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant human full length IDO1 by mass spectrometry based enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IDO1 in recombinant human IFNgamma-induced human HeLa assessed as reduction in kynurenine production incubated for 16 to 24 hrs by colo...More data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Inhibition of recombinant human His-tagged IDO1 (Ala2 to Gly403 residues) expressed in Escherichia coli using tryptophan as substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 1 hr by absorbance b...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IDO1 in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
Affinity DataKd: 1.40E+4nMAssay Description:Binding affinity to ferrous form of human recombinant IDO-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of human TDO2 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataKd: 2.23E+4nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataKd: 320nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygenMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Iteos Therapeutics
Curated by ChEMBL
Iteos Therapeutics
Curated by ChEMBL
Affinity DataIC50: 6.54E+4nMAssay Description:Inhibition of BCRP (unknown origin) transfected in MDCK cells assessed as decrease in pitavastatin transportMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IDO1 in recombinant human IFNgamma and LPS-induced human THP1 assessed as reduction in kynurenine production incubated for 16 to 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of IDO1 in recombinant human IFNgamma and LPS-induced human leukocytes assessed as reduction in kynurenine production by LC-MS/MS methodMore data for this Ligand-Target Pair